Vaccine Development Targeting Quorum Sensing of Superbugs

Ace Therapeutics is a leading preclinical CRO dedicated to providing innovative solutions in the fight against antibiotic-resistant superbugs. Our team of experienced scientists and technicians is committed to developing cutting-edge vaccine strategies that specifically target quorum sensing mechanisms in superbugs, with the goal of neutralizing their virulence and preventing the spread of drug-resistant infections.

Quorum Sensing in Superbugs

Quorum sensing is a complex communication system that allows bacteria to coordinate their behavior and establish infection in the host. Superbugs, such as methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and multidrug-resistant Pseudomonas aeruginosa, are notorious for their ability to communicate through quorum sensing, which contributes to their virulence and makes them difficult to treat with traditional antibiotics.

Fig. 1 Schematic diagram of the quorum-sensing inhibitor mechanism. (Davies A H, et al., 2011)

We recognize the urgent need for innovative approaches to combat these superbugs, and our vaccine development services offer customized solutions to target quorum sensing and disrupt the communication networks of these pathogens.

Vaccine Development Services Targeting Quorum Sensing of Superbug

Our vaccine development services are designed to provide a comprehensive and integrated approach to vaccine development, from initial analysis of quorum sensing mechanisms in superbugs to preclinical evaluation of vaccine candidates.

Identify the specific superbugs. To develop a vaccine that targets quorum sensing in superbugs, it's essential to identify the specific bacterial strains that pose the greatest threat. This requires a thorough understanding of the different types of superbugs and their antibiotic resistance mechanisms.
Target the quorum sensing molecules. Targeting quorum sensing molecules with vaccines could disrupt the communication and potentially prevent antibiotic resistance. We can identify the specific quorum-sensing molecules used by superbugs, which could be targeted with vaccines.
Targeted vaccines design. Targeted vaccines are designed to trigger an immune response against the quorum-sensing molecules, preventing their ability to communicate and coordinate behavior. Researchers and pharmaceutical companies can collaborate and work together with us to advance the development of such vaccines.

Vaccine Development Strategies

Live attenuated vaccines. By targeting quorum sensing mechanisms in superbugs, our live attenuated vaccines can disrupt their communication networks and prevent the establishment of infection in the host.
Subunit vaccines. Our subunit vaccines targeting quorum sensing in superbugs are designed to elicit a targeted immune response against the key components involved in quorum sensing, effectively disrupting the communication networks of these pathogens and reducing their virulence.
Conjugate vaccines. Our conjugate vaccines targeting quorum sensing in superbugs are designed to specifically target the signaling molecules or receptors involved in quorum sensing, disrupting their communication networks and inhibiting their ability to coordinate infection.
DNA vaccines. Our DNA vaccines are designed to trigger a robust and specific immune response against the quorum sensing components of these pathogens, effectively disrupting their communication networks and reducing their virulence.

Service Features

Our vaccine development services feature a wide range of service features that set us apart from the competition.

We offer fast turnaround times, as we understand the urgent need for effective solutions to combat superbugs.
Our team of experts is highly skilled and experienced in vaccine development, ensuring that our clients receive top-notch technical expertise and scientific knowledge.
We also provide cost-effective solutions, as we believe that innovative vaccine development should be accessible.

References

Zhao X, et al. Quorum-sensing regulation of antimicrobial resistance in bacteria. Microorganisms, 2020, 8(3): 425.
Lee J, et al. Vaccines targeting quorum sensing in Gram-negative bacteria. Journal of Biotechnology, 2016, 219: 32-43.
Rampioni G, et al. Development of Anti-Virulence Approaches for Candida albicans through a Quorum Sensing Modulation Perspective. Journal of Fungi, 2020, 6.1: 6.

All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.